PUBLICATION
Animal models of fibrodysplasia ossificans progressiva
- Authors
- LaBonty, M., Yelick, P.C.
- ID
- ZDB-PUB-171204-4
- Date
- 2017
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 247(2): 279-288 (Review)
- Registered Authors
- Yelick, Pamela C.
- Keywords
- Zebrafish disease model, genetic models, rare disease
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Disease Progression
- Humans
- Ossification, Heterotopic/etiology
- Ossification, Heterotopic/genetics
- Ossification, Heterotopic/pathology*
- Zebrafish
- PubMed
- 29139166 Full text @ Dev. Dyn.
Citation
LaBonty, M., Yelick, P.C. (2017) Animal models of fibrodysplasia ossificans progressiva. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(2):279-288.
Abstract
Fibrodysplasia Ossificans Progressiva is a rare human disease of heterotopic ossification. FOP patients experience progressive development of ectopic bone within fibrous tissues that contributes to a gradual loss of mobility and can lead to early mortality. Due to lack of understanding of the etiology and progression of human FOP, and the fact that surgical interventions often exacerbate FOP disease progression, alternative therapeutic methods are needed, including modeling in animals, to study and improve understanding of human FOP. In this review we provide an overview of the existing animal models of FOP and the key mechanistic findings from each. In addition, we highlight the specific advantages of a new adult zebrafish model, generated by our lab, to study human FOP. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping