PUBLICATION
Chlorogenic acid rescues sensorineural auditory function in a diabetic animal model
- Authors
- Hong, B.N., Nam, Y.H., Woo, S.H., Kang, T.H.
- ID
- ZDB-PUB-171025-12
- Date
- 2017
- Source
- Neuroscience letters 640: 64-69 (Journal)
- Registered Authors
- Keywords
- Chlorogenic acid, Diabetic mellitus, Mice, Sensorineural auditory function
- MeSH Terms
-
- Alloxan
- Animals
- Apoptosis
- Auditory Pathways/drug effects
- Auditory Pathways/physiopathology
- Chlorogenic Acid/pharmacology*
- Chlorogenic Acid/therapeutic use
- Cochlear Nerve/drug effects
- Cochlear Nerve/physiopathology
- Diabetes Complications/drug therapy*
- Diabetes Complications/pathology
- Diabetes Complications/physiopathology
- Evoked Potentials, Auditory, Brain Stem/drug effects
- Hair Cells, Auditory, Outer/drug effects
- Hair Cells, Auditory, Outer/pathology
- Hearing Loss, Sensorineural/drug therapy*
- Hearing Loss, Sensorineural/pathology
- Hearing Loss, Sensorineural/physiopathology
- Hypoglycemic Agents/pharmacology*
- Hypoglycemic Agents/therapeutic use
- Larva/cytology
- Larva/drug effects*
- Male
- Mice, Inbred C57BL
- Mice, Transgenic
- Zebrafish
- PubMed
- 28093303 Full text @ Neurosci. Lett.
Citation
Hong, B.N., Nam, Y.H., Woo, S.H., Kang, T.H. (2017) Chlorogenic acid rescues sensorineural auditory function in a diabetic animal model. Neuroscience letters. 640:64-69.
Abstract
Recently, many studies have reported that sensorineural hearing impairment related to neurological disorders may be caused by diabetes mellitus. However, to date, only a small number of studies have investigated the treatment of sensorineural hearing impairment. In the present study, the effects of chlorogenic acid on diabetic auditory pathway impairment were evaluated by neuro-electrical physiological measurements and morphological investigations. We have shown that CA efficiently prevents the progression of auditory pathway dysfunction caused by DM using auditory brainstem responses and auditory middle latency responses in mice. Additionally, using transient-evoked otoacoustic emissions measurement and scanning electron microscope observation of hair cells in DM mice, we found that CA may aid in the recovery from outer hair cell and otic hair cell damage. In conclusion, CA has beneficial effects for the management of diabetic sensorineural auditory dysfunction.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping