PUBLICATION
The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review
- Authors
- Fontana, B.D., Mezzomo, N.J., Kalueff, A.V., Rosemberg, D.B.
- ID
- ZDB-PUB-171011-20
- Date
- 2017
- Source
- Experimental neurology 299(Pt A): 157-171 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- Brain function, Neurological diseases, Neuropsychopharmacology, Psychiatric disorder, Zebrafish
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Humans
- Mental Disorders/genetics*
- Mental Disorders/physiopathology*
- Nervous System Diseases/genetics*
- Nervous System Diseases/physiopathology*
- Zebrafish/genetics*
- Zebrafish/physiology*
- PubMed
- 28987462 Full text @ Exp. Neurol.
Citation
Fontana, B.D., Mezzomo, N.J., Kalueff, A.V., Rosemberg, D.B. (2017) The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review. Experimental neurology. 299(Pt A):157-171.
Abstract
Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their genetic tractability, molecular/physiological conservation, small body size, ease of experimental manipulations in vivo, and rich behavioral repertoire. Zebrafish models and tests are particularly useful in genetics research, neurophenotyping, CNS drug screening, as well as modeling complex neurological and psychiatric disorders. Here, we discuss selected examples of successful application of zebrafish models to mimicking various aspects of brain pathology, and emphasize their developing utility for studying the underlying molecular and genetic mechanisms. We also summarize recent advances in zebrafish-based CNS disease modeling, and outline new research strategies that may significantly improve translational neuroscience and experimental neurology research, and drug discovery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping