ZFIN ID: ZDB-PUB-170922-16
Morphogenesis and evolution of vertebrate appendicular muscle formation
Cole, N.J., Neyt, C., Currie, P.D.
In vertebrate evolution the advent of terrestrial tetrapod species resulted in a
shift in locomotor strategies. Although the fossil record gives some
understanding as to how the appendicular skeleton of the fin has evolved
into limbs it provides little insight into how these muscles arose.
This study is specifically concerned with determining how the muscles of
the fins and limbs have evolved within the vertebrate lineage. Neyt et al.,
2000, Haines and Currie 2001 previously defined both primitive and
derived modes of fin and limb muscle formation. We aim to generate a
detailed understanding of the morphological and genetic basis for these two
Previous analysis relates specifically to muscle formation in the pectoral
fin (forerunner of the tetrapod forelimb). Almost no information exists as
to the nature of muscle formation in the pelvic fin (forerunner to
hindlimb). This is a matter of some importance as it is well characterised
that fore and hind limbs in amniote species both utilise the same derived
mechanism of LBX positive, mesenchymal migratory myoblasts to
generate limb musculature.
We have examined the mechanisms that are utilised to generate muscle
formation within the paired fins of zebrafish and phylogenetically diverse
range of vertebrate species
Our initial observations suggest some differences between pectoral and
pelvic fin muscle formation pointing to the potential importance of pelvic
fin muscle evolution for the tetrapod transition on to land.
ADDITIONAL INFORMATIONNo data available