PUBLICATION
Dual tumor-targeted poly(lactic-co-glycolic acid)-polyethylene glycol-folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery.
- Authors
- Chen, J., Wu, Q., Luo, L., Wang, Y., Zhong, Y., Dai, H.B., Sun, D., Luo, M.L., Wu, W., Wang, G.X.
- ID
- ZDB-PUB-170830-13
- Date
- 2017
- Source
- International Journal of Nanomedicine 12: 5745-5760 (Journal)
- Registered Authors
- Wang, Guixue, Wang, Yi
- Keywords
- biodegradable nanoparticle, drug delivery, efficient, security, tumor target, tumor therapy
- MeSH Terms
-
- Animals
- Antineoplastic Agents/administration & dosage*
- Antineoplastic Agents/pharmacokinetics
- Antineoplastic Agents/pharmacology
- Cell Survival/drug effects
- Doxorubicin/administration & dosage*
- Doxorubicin/pharmacokinetics
- Doxorubicin/pharmacology
- Drug Carriers/administration & dosage*
- Drug Carriers/pharmacokinetics
- Drug Delivery Systems/methods
- Embryo, Nonmammalian/drug effects
- Folic Acid/chemistry
- Folic Acid/pharmacology*
- HeLa Cells
- Humans
- Lactic Acid/chemistry
- Materials Testing
- Nanoparticles/administration & dosage*
- Nanoparticles/chemistry
- Nanoparticles/toxicity
- Polyethylene Glycols/chemistry
- Polyglactin 910
- Polyglycolic Acid/chemistry
- Rabbits
- Tetrazolium Salts
- Thiazoles
- Zebrafish/embryology
- PubMed
- 28848351 Full text @ Int. J. Nanomedicine
Citation
Chen, J., Wu, Q., Luo, L., Wang, Y., Zhong, Y., Dai, H.B., Sun, D., Luo, M.L., Wu, W., Wang, G.X. (2017) Dual tumor-targeted poly(lactic-co-glycolic acid)-polyethylene glycol-folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery.. International Journal of Nanomedicine. 12:5745-5760.
Abstract
Further specific target-ability development of biodegradable nanocarriers is extremely important to promote their security and efficiency in antitumor drug-delivery applications. In this study, a facilely prepared poly(lactic-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-folic acid (FA) copolymer was able to self-assemble into nanoparticles with favorable hydrodynamic diameters of around 100 nm and negative surface charge in aqueous solution, which was expected to enhance intracellular antitumor drug delivery by advanced dual tumor-target effects, ie, enhanced permeability and retention induced the passive target, and FA mediated the positive target. Fluorescence-activated cell-sorting and confocal laser-scanning microscopy results confirmed that doxorubicin (model drug) loaded into PLGA-PEG-FA nanoparticles was able to be delivered efficiently into tumor cells and accumulated at nuclei. In addition, all hemolysis, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, and zebrafish-development experiments demonstrated that PLGA-PEG-FA nanoparticles were biocompatible and secure for biomedical applications, even at high polymer concentration (0.1 mg/mL), both in vitro and in vivo. Therefore, PLGA-PEG-FA nanoparticles provide a feasible controlled-release platform for secure and efficient antitumor drug delivery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
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Mapping