ZFIN ID: ZDB-PUB-170829-8
Zygotic Genome Activators, Developmental Timing, and Pluripotency
Onichtchouk, D., Driever, W.
Date: 2016
Source: Current topics in developmental biology   116: 273-97 (Chapter)
Registered Authors: Driever, Wolfgang
Keywords: Blastula, Differentiation, Embryo, Embryonic stem cells, Gene regulatory network, Oct4, Pattern formation, Pluripotency, Pou5f3, Zygotic genome activation
MeSH Terms:
  • Animals
  • Cell Lineage
  • Evolution, Molecular
  • Female
  • Gene Expression Regulation, Developmental*
  • Gene Regulatory Networks*
  • Humans
  • Mammals/embryology
  • Mammals/genetics
  • Nanog Homeobox Protein/genetics
  • Nanog Homeobox Protein/metabolism
  • Octamer Transcription Factor-3/genetics
  • Octamer Transcription Factor-3/metabolism
  • Pluripotent Stem Cells*
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • Zygote*
PubMed: 26970624 Full text @ Curr. Top. Dev. Biol.
The transcription factors Pou5f1, Sox2, and Nanog are central regulators of pluripotency in mammalian ES and iPS cells. In vertebrate embryos, Pou5f1/3, SoxB1, and Nanog control zygotic genome activation and participate in lineage decisions. We review the current knowledge of the roles of these genes in developing vertebrate embryos from fish to mammals and suggest a model for pluripotency gene regulatory network functions in early development.