PUBLICATION
Corepressor diversification by alternative mRNA splicing is species specific
- Authors
- Privalsky, M.L., Snyder, C.A., Goodson, M.L.
- ID
- ZDB-PUB-170810-12
- Date
- 2016
- Source
- BMC Evolutionary Biology 16: 221 (Journal)
- Registered Authors
- Keywords
- Corepressor, Evolution, NCoR, SMRT, mRNA splicing
- MeSH Terms
-
- Alternative Splicing/genetics*
- Animals
- Co-Repressor Proteins/genetics*
- Co-Repressor Proteins/metabolism
- Evolution, Molecular*
- Humans
- Liver/metabolism
- Mice
- Nuclear Receptor Co-Repressor 1/genetics
- Nuclear Receptor Co-Repressor 1/metabolism
- Nuclear Receptor Co-Repressor 2/genetics
- Nuclear Receptor Co-Repressor 2/metabolism
- Opossums/genetics
- RNA Splice Sites/genetics
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Sheep/genetics
- Species Specificity
- Xenopus/genetics
- Zebrafish/genetics
- PubMed
- 27756201 Full text @ BMC Evol. Biol.
Citation
Privalsky, M.L., Snyder, C.A., Goodson, M.L. (2016) Corepressor diversification by alternative mRNA splicing is species specific. BMC Evolutionary Biology. 16:221.
Abstract
Background SMRT and NCoR are corepressor paralogs that help mediate transcriptional repression by a variety of transcription factors, including the nuclear hormone receptors. The functions of both corepressors are extensively diversified in mice by alternative mRNA splicing, generating a series of protein variants that differ in different tissues and that exert different, even diametrically opposite, biochemical and biological effects from one another.
Results We report here that the alternative splicing previously reported for SMRT appears to be a relatively recent evolutionary phenomenon, with only one of these previously identified sites utilized in a teleost fish and a limited additional number of the additional known sites utilized in a bird, reptile, and marsupial. In contrast, extensive SMRT alternative splicing at these sites was detected among the placental mammals. The alternative splicing of NCoR previously identified in mice (and shown to regulate lipid and carbohydrate metabolism) is likely to have arisen separately and after that of SMRT, and includes an example of convergent evolution.
Conclusions We propose that the functions of both SMRT and NCoR have been diversified by alternative splicing during evolution to allow customization for different purposes in different tissues and different species.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping