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ZFIN ID: ZDB-PUB-170627-5
The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision.
Vinberg, F., Wang, T., De Maria, A., Zhao, H., Bassnett, S., Chen, J., Kefalov, V.J.
Date: 2017
Source: eLIFE   6: (Journal)
Registered Authors:
Keywords: mouse, neuroscience, rhesus macaque, zebrafish
MeSH Terms:
  • Animals
  • Antiporters/deficiency
  • Antiporters/metabolism*
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Primates
  • Retinal Cone Photoreceptor Cells/physiology*
  • Sodium-Calcium Exchanger/metabolism*
  • Vision, Ocular*
  • Zebrafish
PubMed: 28650316 Full text @ Elife
Calcium (Ca2+) plays an important role in the function and health of neurons. In vertebrate cone photoreceptors, Ca2+ controls photoresponse sensitivity, kinetics, and light adaptation. Despite the critical role of Ca2+ in supporting the function and survival of cones, the mechanism for its extrusion from cone outer segments is not well understood. Here, we show that the Na+/Ca2+, K+ exchanger NCKX4 is expressed in zebrafish, mouse, and primate cones. Functional analysis of NCKX4-deficient mouse cones revealed that this exchanger is essential for the wide operating range and high temporal resolution of cone-mediated vision. We show that NCKX4 shapes the cone photoresponse together with the cone-specific NCKX2: NCKX4 acts early to limit response amplitude, while NCKX2 acts late to further accelerate response recovery. The regulation of Ca2+ by NCKX4 in cones is a novel mechanism that supports their ability to function as daytime photoreceptors and promotes their survival.