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ZFIN ID: ZDB-PUB-170505-8
Little Fish, Big Data: Zebrafish as a Model for Cardiovascular and Metabolic Disease
Gut, P., Reischauer, S., Stainier, D.Y.R., Arnaout, R.
Date: 2017
Source: Physiological reviews   97: 889-938 (Review)
Registered Authors: Gut, Philipp, Reischauer, Sven, Stainier, Didier
Keywords: none
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Cardiovascular Agents/pharmacology
  • Cardiovascular Diseases/drug therapy
  • Cardiovascular Diseases/genetics*
  • Cardiovascular Diseases/metabolism
  • Cardiovascular Diseases/physiopathology
  • Disease Models, Animal
  • Drug Discovery/methods*
  • Genetic Predisposition to Disease
  • Humans
  • Metabolic Diseases/drug therapy
  • Metabolic Diseases/genetics*
  • Metabolic Diseases/metabolism
  • Metabolic Diseases/physiopathology
  • Phenotype
  • Species Specificity
  • Zebrafish/genetics*
  • Zebrafish/metabolism
PubMed: 28468832 Full text @ Physiol. Rev.
The burden of cardiovascular and metabolic diseases worldwide is staggering. The emergence of systems approaches in biology promises new therapies, faster and cheaper diagnostics, and personalized medicine. However, a profound understanding of pathogenic mechanisms at the cellular and molecular levels remains a fundamental requirement for discovery and therapeutics. Animal models of human disease are cornerstones of drug discovery as they allow identification of novel pharmacological targets by linking gene function with pathogenesis. The zebrafish model has been used for decades to study development and pathophysiology. More than ever, the specific strengths of the zebrafish model make it a prime partner in an age of discovery transformed by big-data approaches to genomics and disease. Zebrafish share a largely conserved physiology and anatomy with mammals. They allow a wide range of genetic manipulations, including the latest genome engineering approaches. They can be bred and studied with remarkable speed, enabling a range of large-scale phenotypic screens. Finally, zebrafish demonstrate an impressive regenerative capacity scientists hope to unlock in humans. Here, we provide a comprehensive guide on applications of zebrafish to investigate cardiovascular and metabolic diseases. We delineate advantages and limitations of zebrafish models of human disease and summarize their most significant contributions to understanding disease progression to date.