PUBLICATION

Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies

Authors
Prince, V.E., Anderson, R.M., Dalgin, G.
ID
ZDB-PUB-170326-11
Date
2017
Source
Current topics in developmental biology   124: 235-276 (Chapter)
Registered Authors
Anderson, Ryan, Dalgin, Gokhan, Prince, Victoria E.
Keywords
Beta cell, Diabetes, Pancreas, Regeneration, Zebrafish
MeSH Terms
  • Animals
  • Diabetes Mellitus/therapy*
  • Insulin-Secreting Cells/cytology
  • Insulin-Secreting Cells/transplantation
  • Pancreas/cytology
  • Pancreas/embryology*
  • Regeneration*
  • Zebrafish/embryology*
  • Zebrafish/genetics
PubMed
28335861 Full text @ Curr. Top. Dev. Biol.
Abstract
The zebrafish pancreas shares its basic organization and cell types with the mammalian pancreas. In addition, the developmental pathways that lead to the establishment of the pancreatic islets of Langherhans are generally conserved from fish to mammals. Zebrafish provides a powerful tool to probe the mechanisms controlling establishment of the pancreatic endocrine cell types from early embryonic progenitor cells, as well as the regeneration of endocrine cells after damage. This knowledge is, in turn, applicable to refining protocols to generate renewable sources of human pancreatic islet cells that are critical for regulation of blood sugar levels. Here, we review how previous and ongoing studies in zebrafish and beyond are influencing the understanding of molecular mechanisms underlying various forms of diabetes and efforts to develop cell-based approaches to cure this increasingly widespread disease.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping