ZFIN ID: ZDB-PUB-170326-11
Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies
Prince, V.E., Anderson, R.M., Dalgin, G.
Date: 2017
Source: Current topics in developmental biology   124: 235-276 (Chapter)
Registered Authors: Anderson, Ryan, Dalgin, Gokhan, Prince, Victoria E.
Keywords: Beta cell, Diabetes, Pancreas, Regeneration, Zebrafish
MeSH Terms:
  • Animals
  • Diabetes Mellitus/therapy*
  • Insulin-Secreting Cells/cytology
  • Insulin-Secreting Cells/transplantation
  • Pancreas/cytology
  • Pancreas/embryology*
  • Regeneration*
  • Zebrafish/embryology*
  • Zebrafish/genetics
PubMed: 28335861 Full text @ Curr. Top. Dev. Biol.
The zebrafish pancreas shares its basic organization and cell types with the mammalian pancreas. In addition, the developmental pathways that lead to the establishment of the pancreatic islets of Langherhans are generally conserved from fish to mammals. Zebrafish provides a powerful tool to probe the mechanisms controlling establishment of the pancreatic endocrine cell types from early embryonic progenitor cells, as well as the regeneration of endocrine cells after damage. This knowledge is, in turn, applicable to refining protocols to generate renewable sources of human pancreatic islet cells that are critical for regulation of blood sugar levels. Here, we review how previous and ongoing studies in zebrafish and beyond are influencing the understanding of molecular mechanisms underlying various forms of diabetes and efforts to develop cell-based approaches to cure this increasingly widespread disease.