PUBLICATION
Danio rerio: Small Fish Making a Big Splash in Leukemia.
- Authors
- Squiban, B., Frazer, J.K.
- ID
- ZDB-PUB-170214-328
- Date
- 2014
- Source
- Current pathobiology reports 2: 61-73 (Review)
- Registered Authors
- Frazer, Kimble, Squiban, Barbara
- Keywords
- Drug Screen, Leukemia, Model for pathobiology, Transgenesis, Transplantation, Zebrafish
- MeSH Terms
- none
- PubMed
- 26269780 Full text @ Curr Pathobiol Rep
Citation
Squiban, B., Frazer, J.K. (2014) Danio rerio: Small Fish Making a Big Splash in Leukemia.. Current pathobiology reports. 2:61-73.
Abstract
Zebrafish (Danio rerio) are widely used for developmental biology studies. In the past decade, D. rerio have become an important oncology model as well. Leukemia is one type of cancer where zebrafish are particularly valuable. As vertebrates, fish have great anatomic and biologic similarity to humans, including their hematopoietic and immune systems. As an experimental platform, D. rerio offer many advantages that mammalian models lack. These include their ease of genetic manipulation, capacity for imaging, and suitability for large-scale phenotypic and drug screens. In this review, we present examples of these strategies and others to illustrate how zebrafish have been and can be used to study leukemia. Besides appraising the techniques researchers apply and introducing the leukemia models they have created, we also highlight recent and exciting discoveries made using D. rerio with an eye to where the field is likely headed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping