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ZFIN ID: ZDB-PUB-161209-6
Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model
Park, C.M., Kim, H.M., Kim, D.H., Han, H.J., Noh, H., Jang, J.H., Park, S.H., Chae, H.J., Chae, S.W., Ryu, E.K., Lee, S., Liu, K., Liu, H., Ahn, J.S., Kim, Y.O., Kim, B.Y., Soung, N.K.
Date: 2016
Source: Molecules and cells   39(12): 855-861 (Journal)
Registered Authors:
Keywords: none
MeSH Terms:
  • Animals
  • Bone Marrow Cells/cytology
  • Bone Marrow Cells/drug effects*
  • Cell Differentiation/drug effects
  • Ginsenosides/pharmacology*
  • Macrophages/cytology
  • Macrophages/drug effects*
  • Mice
  • Osteoclasts/cytology
  • Osteoclasts/drug effects*
  • Zebrafish
PubMed: 27927007 Full text @ Mol. Cells
Ginsenosides, which are the active materials of ginseng, have biological functions that include anti-osteoporotic effects. Aqueous ginseng extract inhibits osteoclast differentiation induced by receptor activator of NF-κB ligand (RANKL). Aqueous ginseng extract produces chromatography peaks characteristic of ginsenosides. Among these peaks, ginsenoside Re is a major component. However, the preventive effects of ginsenoside Re against osteoclast differentiation are not known. We studied the effect of ginsenoside Re on osteoclast differentiation, RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity, and formation of multinucleated osteoclasts in vitro. Ginsenoside Re hampered osteoclast differentiation in a dose-dependent manner. In an in vivo zebrafish model, aqueous ginseng extract and ginsenoside Re had anti-osteoclastogenesis effects. These findings suggest that both aqueous ginseng extract and ginsenoside Re prevent bone resorption by inhibiting osteoclast differentiation. Ginsenoside Re could be important for promoting bone health.