PUBLICATION
Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes
- Authors
- Skjaerven, K.H., Jakt, L.M., Dahl, J.A., Espe, M., Aanes, H., Hamre, K., Fernandes, J.M.
- ID
- ZDB-PUB-161013-2
- Date
- 2016
- Source
- Scientific Reports 6: 34535 (Journal)
- Registered Authors
- Fernandes, Jorge
- Keywords
- Embryology, Environmental impact, Gastrulation
- MeSH Terms
-
- Animals
- Apolipoproteins*/biosynthesis
- Apolipoproteins*/immunology
- Avitaminosis/embryology
- Avitaminosis/immunology
- Female
- Gene Expression Regulation, Developmental*
- Lipid Metabolism/immunology*
- Male
- Zebrafish*/embryology
- Zebrafish*/immunology
- Zebrafish Proteins*/biosynthesis
- Zebrafish Proteins*/immunology
- PubMed
- 27731423 Full text @ Sci. Rep.
Citation
Skjaerven, K.H., Jakt, L.M., Dahl, J.A., Espe, M., Aanes, H., Hamre, K., Fernandes, J.M. (2016) Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes. Scientific Reports. 6:34535.
Abstract
World Health Organization is concerned for parental vitamin deficiency and its effect on offspring health. This study examines the effect of a marginally dietary-induced parental one carbon (1-C) micronutrient deficiency on embryonic gene expression using zebrafish. Metabolic profiling revealed a reduced 1-C cycle efficiency in F0 generation. Parental deficiency reduced the fecundity and a total of 364 genes were differentially expressed in the F1 embryos. The upregulated genes (53%) in the deficient group were enriched in biological processes such as immune response and blood coagulation. Several genes encoding enzymes essential for the 1-C cycle and for lipid transport (especially apolipoproteins) were aberrantly expressed. We show that a parental diet deficient in micronutrients disturbs the expression in descendant embryos of genes associated with overall health, and result in inherited aberrations in the 1-C cycle and lipid metabolism. This emphasises the importance of parental micronutrient status for the health of the offspring.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping