PUBLICATION
Transcriptional control by G-quadruplexes: in vivo roles and perspectives for specific intervention
- Authors
- Armas, P., David, A., Calcaterra, N.
- ID
- ZDB-PUB-161007-28
- Date
- 2017
- Source
- Transcription 8(1): 21-25 (Review)
- Registered Authors
- Calcaterra, Nora
- Keywords
- antisense, embryonic development, noggin3, oligonucleotide, zebrafish
- MeSH Terms
-
- Animals
- DNA/chemistry*
- G-Quadruplexes
- Gene Expression Regulation, Developmental
- Models, Molecular
- Nucleic Acid Conformation
- Transcription, Genetic*
- Zebrafish/embryology*
- Zebrafish/genetics
- PubMed
- 27696937 Full text @ Transcription
Citation
Armas, P., David, A., Calcaterra, N. (2017) Transcriptional control by G-quadruplexes: in vivo roles and perspectives for specific intervention. Transcription. 8(1):21-25.
Abstract
G-quadruplexes are non-canonical DNA secondary structures involved in several genomic and molecular processes. Here we summarize the main G-quadruplex features and evidences proving the in vivo role on the transcriptional regulation of genes required for zebrafish embryonic development. We also discuss alternative strategies for specifically interfering G-quadruplex in vivo.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping