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ZIRC
ZFIN ID: ZDB-PUB-160725-38
Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1
Ocaña, O.H., Córcoles, R., Fabra, A., Moreno-Bueno, G., Acloque, H., Vega, S.,Barrallo-Gimeno, A., Cano, A., Nieto, M.A.
Date: 2012
Source: Cancer Cell   22(6): 709-724 (Journal)
Registered Authors: Barrallo Gimeno, Alejandro, Córcoles, Rebeca, Nieto, Angela, Ocaña, Oscar H., Vega, Sonia
Keywords: none
MeSH Terms:
  • Biomarkers, Tumor/genetics
  • Biomarkers, Tumor/metabolism
  • Breast Neoplasms/genetics
  • Breast Neoplasms/metabolism
  • Breast Neoplasms/pathology*
  • Cell Line, Tumor
  • Cell Movement/genetics
  • Cell Movement/physiology
  • Epithelial Cells/metabolism
  • Epithelial Cells/pathology
  • Epithelial-Mesenchymal Transition/genetics
  • Epithelial-Mesenchymal Transition/physiology*
  • Female
  • Homeodomain Proteins/genetics
  • Homeodomain Proteins/metabolism
  • Homeodomain Proteins/physiology*
  • Humans
  • MCF-7 Cells
  • Middle Aged
  • Neoplasm Metastasis
  • Prognosis
  • Retrospective Studies
  • Stem Cells/metabolism
  • Stem Cells/pathology
PubMed: 23201163 Full text @ Cancer Cell
FIGURES
ABSTRACT
The epithelial-mesenchymal transition (EMT) is required in the embryo for the formation of tissues for which cells originate far from their final destination. Carcinoma cells hijack this program for tumor dissemination. The relevance of the EMT in cancer is still debated because it is unclear how these migratory cells colonize distant tissues to form macrometastases. We show that the homeobox factor Prrx1 is an EMT inducer conferring migratory and invasive properties. The loss of Prrx1 is required for cancer cells to metastasize in vivo, which revert to the epithelial phenotype concomitant with the acquisition of stem cell properties. Thus, unlike the classical EMT transcription factors, Prrx1 uncouples EMT and stemness, and is a biomarker associated with patient survival and lack of metastasis.
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