PUBLICATION
Antennas of organ morphogenesis: The roles of cilia in vertebrate kidney development
- Authors
- Marra, A.N., Li, Y., Wingert, R.A.
- ID
- ZDB-PUB-160709-9
- Date
- 2016
- Source
- Genesis (New York, N.Y. : 2000) 54(9): 457-69 (Review)
- Registered Authors
- Li, Yue, Marra, Amanda, Wingert, Rebecca
- Keywords
- ciliopathy, development, kidney, mesonephros, metanephros, motile cilia, multiciliated cell, primary cilia, pronephros, zebrafish
- MeSH Terms
-
- Animals
- Cilia
- Humans
- Kidney/cytology*
- Kidney/embryology
- Morphogenesis*
- PubMed
- 27389733 Full text @ Genesis
Citation
Marra, A.N., Li, Y., Wingert, R.A. (2016) Antennas of organ morphogenesis: The roles of cilia in vertebrate kidney development. Genesis (New York, N.Y. : 2000). 54(9):457-69.
Abstract
Cilia arose early during eukaryotic evolution, and their structural components are highly conserved from the simplest prokaryotes to complex metazoan species. In recent years, the role of cilia in the ontogeny of vertebrate organs has received increasing attention due to a staggering correlation between human disease and dysfunctional cilia. In particular, the presence of cilia in both the developing and mature kidney has become a deep area of research due to ciliopathies common to the kidney, such as polycystic kidney disease (PKD). Interestingly, mutations in genes encoding proteins that localize to the cilia cause similar cystic phenotypes in kidneys of various vertebrates, suggesting an essential role for cilia in kidney organogenesis and homeostasis as well. Importantly, the genes so far identified in kidney disease have conserved functions across species, whose kidneys include both primary and motile cilia. Here, we aim to provide a comprehensive description of cilia and their role in kidney development, as well as highlight the usefulness of the zebrafish embryonic kidney as a model to further understand the function of cilia in kidney health. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping