PUBLICATION

Effects of tris(2-butoxyethyl) phosphate exposure on endocrine systems and reproduction of zebrafish (Danio rerio)

Authors
Kwon, B., Shin, H., Moon, H.B., Ji, K., Kim, K.T.
ID
ZDB-PUB-160502-3
Date
2016
Source
Environmental pollution (Barking, Essex : 1987)   214: 568-574 (Journal)
Registered Authors
Keywords
Endocrine disruption, HPG axis, Organophosphate flame retardants, TBEOP, Zebrafish
MeSH Terms
  • Animals
  • Endocrine System/drug effects*
  • Estradiol/metabolism
  • Flame Retardants/toxicity*
  • Male
  • Organophosphorus Compounds/toxicity*
  • Reproduction/drug effects*
  • Up-Regulation
  • Water Pollutants, Chemical/toxicity*
  • Zebrafish/growth & development
  • Zebrafish/physiology*
PubMed
27131816 Full text @ Environ. Pollut.
CTD
27131816
Abstract
Tris(2-butoxyethyl) phosphate (TBEOP), a widely used organophosphate flame retardant, has frequently been detected both in the environment and the biota. However, limited information is available on the effects of TBEOP on the endocrine system and its underlying mechanisms. We exposed adult zebrafish pairs to TBEOP at concentrations of 0, 2.1, 11, and 118 μg/L for 21 d, and investigated the effects on gene transcription and hormone production related to the hypothalamic-pituitary-gonadal (HPG) axis, and on reproduction. The adverse effects on the F1 generation were further examined. In male fish, plasma concentrations of 17β-estradiol were significantly increased along with up-regulation of cyp19a. Exposure to TBEOP at 118 μg/L led to a significant decrease in average egg production. Exposure of the F0 generation to TBEOP delayed hatching and lowered hatching rates in the F1 generation. The results demonstrate that exposure to TBEOP at environmentally relevant concentration levels could affect the sex hormone balance by altering regulatory circuits of the HPG axis, eventually leading to disruption of reproductive performance and the development of offspring.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping