ZFIN ID: ZDB-PUB-160401-17
Blood, blebs and lumen expansion
Reichman-Fried, M., Raz, E.
Date: 2016
Source: Nature cell biology   18: 366-7 (Review)
Registered Authors: Raz, Erez, Reichman-Fried, Michal
Keywords: Angiogenesis, Microscopy, Myosin, Zebrafish
MeSH Terms:
  • Animals
  • Blood Vessels/embryology*
  • Female
  • Male
  • Morphogenesis*
  • Neovascularization, Physiologic*
PubMed: 27027487 Full text @ Nat. Cell Biol.
ABSTRACT
A powerful combination of cell labelling, genetic tools and rapid imaging techniques in vivo has now led to a high-resolution description of lumen formation during angiogenesis in zebrafish. The study reveals a haemodynamic-force-driven and myosin-II-dependent cellular mechanism (termed inverse membrane blebbing) as the basis for lumen expansion in unicellular and multicellular angiogenic sprouts.
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