PUBLICATION

Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo

Authors
Yoshimatsu, T., D'Orazi, F.D., Gamlin, C.R., Suzuki, S.C., Suli, A., Kimelman, D., Raible, D.W., Wong, R.O.
ID
ZDB-PUB-160204-8
Date
2016
Source
Nature communications   7: 10590 (Journal)
Registered Authors
Kimelman, David, Raible, David, Suli, Arminda, Wong, Rachel
Keywords
Biological sciences, Cell biology, Developmental biology, Neuroscience
MeSH Terms
  • Animals
  • Cues
  • Dendrites/physiology*
  • Immunohistochemistry
  • Microscopy, Confocal
  • Optical Imaging
  • Regeneration/physiology*
  • Retinal Cone Photoreceptor Cells/physiology*
  • Retinal Horizontal Cells/physiology*
  • Retinal Neurons/physiology
  • Synapses/physiology*
  • Ultraviolet Rays
  • Zebrafish
PubMed
26838932 Full text @ Nat. Commun.
Abstract
Whether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their connectivity upon regeneration of their major input. H3 horizontal cells (HCs) normally avoid red and green cones, and prefer ultraviolet over blue cones. Upon ablation of the major (ultraviolet) input, H3 HCs do not immediately increase connectivity with other cone types. Instead, H3 dendrites retract and re-extend to contact new ultraviolet cones. But, if regeneration is delayed or absent, blue-cone synaptogenesis increases and ectopic synapses are made with red and green cones. Thus, cues directing synapse specificity can be maintained following input loss, but only within a limited time period. Further, we postulate that signals from the major input that shape the H3 HC's wiring pattern during development persist to restrict miswiring after damage.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes