ZFIN ID: ZDB-PUB-151101-12
Chemical Ototoxicity of the Fish Inner Ear and Lateral Line
Coffin, A.B., Ramcharitar, J.
Date: 2016
Source: Advances in experimental medicine and biology   877: 419-37 (Chapter)
Registered Authors: Coffin, Allison
Keywords: Auditory, Ear, Fish, Hair cell, Lateral line
MeSH Terms:
  • Aminoglycosides/toxicity
  • Animals
  • Anti-Bacterial Agents/toxicity
  • Ear, Inner/drug effects
  • Ear, Inner/pathology
  • Ear, Inner/physiopathology*
  • Fishes/classification
  • Fishes/physiology*
  • Hair Cells, Auditory/drug effects
  • Hair Cells, Auditory/physiology
  • Humans
  • Larva/drug effects
  • Larva/physiology
  • Lateral Line System/drug effects*
  • Lateral Line System/pathology
  • Lateral Line System/physiopathology*
  • Zebrafish/physiology*
PubMed: 26515324 Full text @ Adv. Exp. Med. Biol.
Hair cell-driven mechanosensory systems are crucial for successful execution of a number of behaviors in fishes, and have emerged as good models for exploring questions relevant to human hearing. This review focuses on ototoxic effects in the inner ear and lateral line system of fishes. We specifically examine studies where chemical ototoxins such as aminoglycoside antibiotics have been employed as tools to disable the lateral line. Lateral line ablation results in alterations to feeding behavior and orientation to water current in a variety of species. However, neither behavior is abolished in the presence of additional sensory cues, supporting the hypothesis that many fish behaviors are driven by multisensory integration. Within biomedical research, the larval zebrafish lateral line has become an important model system for understanding signaling mechanisms that contribute to hair cell death and for developing novel pharmacological therapies that protect hair cells from ototoxic damage. Furthermore, given that fishes robustly regenerate damaged hair cells, ototoxin studies in fishes have broadened our understanding of the molecular and genetic events in an innately regenerative system, offering potential targets for mammalian hair cell regeneration. Collectively, studies of fish mechanosensory systems have yielded insight into fish behavior and in mechanisms of hair cell death, protection, and regeneration.