ZFIN ID: ZDB-PUB-150825-56
Differential embryotoxicity of the organic pollutants in rural and urban air particles
Mesquita, S.R., van Drooge, B.L., Oliveira, E., Grimalt, J.O., Barata, C., Vieira, N., Guimarães, L., Piña, B.
Date: 2015
Source: Environmental pollution (Barking, Essex : 1987)   206: 535-542 (Journal)
Registered Authors: Piña, Benjamin
Keywords: Air pollution, Air quality, Danio rerio, Embryo toxicity, GC–MS, PM10, Toxicogenomics
Microarrays: GEO:GSE53522
MeSH Terms:
  • Air Pollutants/analysis
  • Air Pollutants/toxicity*
  • Animals
  • Embryo, Nonmammalian/drug effects
  • Embryonic Development/drug effects*
  • Embryonic Development/genetics
  • Environmental Monitoring/methods*
  • Gene Expression Regulation, Developmental/drug effects
  • Gene Ontology
  • Humans
  • Lens, Crystalline/drug effects
  • Lens, Crystalline/embryology
  • Pancreas/drug effects
  • Pancreas/embryology
  • Particle Size
  • Particulate Matter/analysis
  • Particulate Matter/toxicity*
  • Risk Assessment
  • Rural Health*
  • Urban Health*
  • Zebrafish/embryology
PubMed: 26298234 Full text @ Environ. Pollut.
Airborne particulate matter (PM) is a recognized risk factor for human populations. Here we assessed the toxic potential of the organic constituents from PM collected in urban and rural sites during warm and cold periods of 2012/2013, and fractionated into 6 size fractions. The finest PM fraction (<0.5 μm) showed the highest biological activity (dioxin-like activity and fish embryotoxicity) in all samples, and the maximal activity was observed in rural samples from the cold period. Zebrafish embryo transcriptome analysis showed a strong induction of the AhR signaling pathway correlated to PAH concentrations. Oxidative stress-related genes and pancreatic and eye-lens gene markers appeared de-regulated in embryos exposed to urban extracts, whereas exposure to rural extracts affected genes implicated in basic cellular functions. The observed effects can be directly related to air pollution-related human disorders, suggesting different potential adverse outcomes for human populations exposed to air pollution from specific sources.