ZFIN ID: ZDB-PUB-150219-7
Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model
Heimberger, J., Cade, H.C., Padgett, J., Sittaramane, V., Shaikh, A.
Date: 2015
Source: Bioorganic & medicinal chemistry letters   25(6): 1192-5 (Other)
Registered Authors: Sittaramane, Vinoth
Keywords: Antioxidant properties, Natural products, Total synthesis, Toxicity, Zebrafish
MeSH Terms:
  • Animals
  • Antioxidants/chemical synthesis*
  • Antioxidants/pharmacology
  • Antioxidants/toxicity
  • Cladosporium/chemistry
  • Cladosporium/metabolism
  • Embryo, Nonmammalian/drug effects
  • Embryonic Development/drug effects
  • Fatty Acids, Unsaturated/chemical synthesis*
  • Fatty Acids, Unsaturated/chemistry
  • Fatty Acids, Unsaturated/toxicity
  • Models, Animal
  • Pyrones/chemical synthesis*
  • Pyrones/chemistry
  • Pyrones/toxicity
  • Zebrafish/growth & development
PubMed: 25690788 Full text @ Bioorg. Med. Chem. Lett.
ABSTRACT
Herbarin A and B were isolated from the fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.
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