PUBLICATION

Renal stem cell reprogramming: Prospects in regenerative medicine

Authors
Morales, E.E., Wingert, R.A.
ID
ZDB-PUB-140927-4
Date
2014
Source
World journal of stem cells   6: 458-66 (Review)
Registered Authors
Morales, Elvin, Wingert, Rebecca
Keywords
Differentiation, Induced pluripotent stem cell, Kidney, Regeneration, Renal progenitor, Reprogramming, Stem cell
MeSH Terms
none
PubMed
25258667 Full text @ World J Stem Cells
Abstract
Stem cell therapy is a promising future enterprise for renal replacement in patients with acute and chronic kidney disease, conditions which affect millions worldwide and currently require patients to undergo lifelong medical treatments through dialysis and/or organ transplant. Reprogramming differentiated renal cells harvested from the patient back into a pluripotent state would decrease the risk of tissue rejection and provide a virtually unlimited supply of cells for regenerative medicine treatments, making it an exciting area of current research in nephrology. Among the major hurdles that need to be overcome before stem cell therapy for the kidney can be applied in a clinical setting are ensuring the fidelity and relative safety of the reprogrammed cells, as well as achieving feasible efficiency in the reprogramming processes that are utilized. Further, improved knowledge about the genetic control of renal lineage development is vital to identifying predictable and efficient reprogramming approaches, such as the expression of key modulators or the regulation of gene activity through small molecule mimetics. Here, we discuss several recent advances in induced pluripotent stem cell technologies. We also explore strategies that have been successful in renal progenitor generation, and explore what these methods might mean for the development of cell-based regenerative therapies for kidney disease.
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