PUBLICATION
Functional Architecture of the Retina: Development and Disease
- Authors
- Hoon, M., Okawa, H., Della Santina, L., Wong, R.O.
- ID
- ZDB-PUB-140702-2
- Date
- 2014
- Source
- Progress in Retinal and Eye Research 42C: 44-84 (Review)
- Registered Authors
- Wong, Rachel
- Keywords
- Mouse retina, Primate retina, Retinal cell mosaics, Retinal development, Retinal repair, Retinal synapses, Zebrafish retina
- MeSH Terms
-
- Animals
- Humans
- Morphogenesis
- Retina/anatomy & histology*
- Retina/cytology
- Retina/physiology*
- Retinal Diseases/physiopathology*
- Retinal Neurons/cytology
- Signal Transduction/physiology
- Vision, Ocular/physiology*
- PubMed
- 24984227 Full text @ Prog. Retin. Eye Res.
Citation
Hoon, M., Okawa, H., Della Santina, L., Wong, R.O. (2014) Functional Architecture of the Retina: Development and Disease. Progress in Retinal and Eye Research. 42C:44-84.
Abstract
Structure and function are highly correlated in the vertebrate retina, a sensory tissue that is organized into cell layers with microcircuits working in parallel and together to encode visual information. All vertebrate retinas share a fundamental plan, comprising five major neuronal cell classes with cell body distributions and connectivity arranged in stereotypic patterns. Conserved features in retinal design have enabled detailed analysis and comparisons of structure, connectivity and function across species. Each species, however, can adopt structural and/or functional retinal specializations, implementing variations to the basic design in order to satisfy unique requirements in visual function. Recent advances in molecular tools, imaging and electrophysiological approaches have greatly facilitated identification of the cellular and molecular mechanisms that establish the fundamental organization of the retina and the specializations of its microcircuits during development. Here, we review advances in our understanding of how these mechanisms act to shape structure and function at the single cell level, to coordinate the assembly of cell populations, and to define their specific circuitry. We also highlight how structure is rearranged and function is disrupted in disease, and discuss current approaches to re-establish the intricate functional architecture of the retina.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping