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ZFIN ID: ZDB-PUB-140629-13
Zebrafish models in translational research: tipping the scales toward advancements in human health
Phillips, J.B., Westerfield, M.
Date: 2014
Source: Disease models & mechanisms   7: 739-743 (Review)
Registered Authors: Phillips, Jennifer, Westerfield, Monte
Keywords: Cancer, Individualized medicine, Muscular dystrophy, Tuberculosis, Usher syndrome
MeSH Terms:
  • Animals
  • Disease Models, Animal
  • Genetic Association Studies
  • Health*
  • Humans
  • Models, Genetic
  • Translational Medical Research*
  • Zebrafish/metabolism*
PubMed: 24973743 Full text @ Dis. Model. Mech.
Advances in genomics and next-generation sequencing have provided clinical researchers with unprecedented opportunities to understand the molecular basis of human genetic disorders. This abundance of information places new requirements on traditional disease models, which have the potential to be used to confirm newly identified pathogenic mutations and test the efficacy of emerging therapies. The unique attributes of zebrafish are being increasingly leveraged to create functional disease models, facilitate drug discovery, and provide critical scientific bases for the development of new clinical tools for the diagnosis and treatment of human disease. In this short review and the accompanying poster, we highlight a few illustrative examples of the applications of the zebrafish model to the study of human health and disease.