ZFIN ID: ZDB-PUB-140520-9
Development of the lateral line canal system through a bone remodeling process in zebrafish
Wada, H., Iwasaki, M., Kawakami, K.
Date: 2014
Source: Developmental Biology 392(1): 1-14 (Journal)
Registered Authors: Kawakami, Koichi, Wada, Hironori
Keywords: Bone remodeling, Lateral line, Neuromast, Organ growth, Scale, Zebrafish
MeSH Terms:
  • Alkaline Phosphatase/biosynthesis
  • Alkaline Phosphatase/metabolism
  • Animals
  • Animals, Genetically Modified
  • Bone Remodeling/physiology*
  • Bone and Bones/embryology
  • Embryonic Development
  • Integumentary System
  • Intercellular Signaling Peptides and Proteins/genetics
  • Intercellular Signaling Peptides and Proteins/metabolism
  • Lateral Line System/cytology*
  • Lateral Line System/embryology*
  • Osteoblasts/metabolism
  • Osteoclasts/metabolism
  • Receptor, Macrophage Colony-Stimulating Factor/genetics
  • Transcription Factors/biosynthesis
  • Wnt Signaling Pathway
  • Zebrafish/embryology*
  • Zebrafish Proteins/biosynthesis
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 24836859 Full text @ Dev. Biol.
The lateral line system of teleost fish is composed of mechanosensory receptors (neuromasts), comprising superficial receptors and others embedded in canals running under the skin. Canal diameter and size of the canal neuromasts are correlated with increasing body size, thus providing a very simple system to investigate mechanisms underlying the coordination between organ growth and body size. Here, we examine the development of the trunk lateral line canal system in zebrafish. We demonstrated that trunk canals originate from scales through a bone remodeling process, which we suggest is essential for the normal growth of canals and canal neuromasts. Moreover, we found that lateral line cells are required for the formation of canals, suggesting the existence of mutual interactions between the sensory system and surrounding connective tissues.