PUBLICATION

Pten regulates zebrafish hematopoiesis

Authors
Langenau, D.M.
ID
ZDB-PUB-140226-2
Date
2014
Source
Blood   123(2): 149-150 (Review)
Registered Authors
Langenau, David
Keywords
none
MeSH Terms
  • Animals
  • Cell Differentiation/genetics*
  • Hematopoietic Stem Cells/cytology*
  • Hematopoietic Stem Cells/metabolism*
  • PTEN Phosphohydrolase/genetics*
  • PTEN Phosphohydrolase/metabolism*
PubMed
24408201 Full text @ Blood
Citation
Langenau, D.M. (2014) Pten regulates zebrafish hematopoiesis. Blood. 123(2):149-150.
Abstract

In this issue of Blood, Choorapoikayil et al have used phosphatase and tensin homolog (Pten)–deficient zebrafish to uncover prominent roles for Pten loss in enhancing proliferation of hematopoietic stem cells (HSCs) and eliciting differentiation arrest within lineage-committed blood progenitor cells. These results provide novel insights into the early genetic events that predispose blood cells to malignant transformation.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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