PUBLICATION
Generation and interpretation of FGF morphogen gradients in vertebrates
- Authors
- Bokel, C., and Brand, M.
- ID
- ZDB-PUB-130610-76
- Date
- 2013
- Source
- Current opinion in genetics & development 23(4): 415-22 (Review)
- Registered Authors
- Brand, Michael
- Keywords
- none
- MeSH Terms
-
- Animals
- Endocytosis/genetics*
- Fibroblast Growth Factors/genetics*
- Gene Expression Regulation, Developmental
- Morphogenesis/genetics*
- Receptors, Fibroblast Growth Factor/genetics
- Receptors, Fibroblast Growth Factor/metabolism
- Signal Transduction/genetics
- Vertebrates/genetics
- Vertebrates/growth & development*
- Zebrafish/growth & development
- PubMed
- 23669552 Full text @ Curr. Opin. Genet. Dev.
Citation
Bokel, C., and Brand, M. (2013) Generation and interpretation of FGF morphogen gradients in vertebrates. Current opinion in genetics & development. 23(4):415-22.
Abstract
Signalling via fibroblast growth factors (FGFs) is involved in multiple aspects of vertebrate development. In several instances FGFs act as morphogens, that is secreted signalling molecules that encode positional information in their graded distribution throughout their target tissue. In recent years, work in the zebrafish model system has been instrumental in addressing the cell biological basis of FGF morphogen gradient formation and interpretation. These experiments have benefitted from the optical properties of the zebrafish embryo that render this vertebrate organism particularly suited for advanced microscopic and biophysical approaches.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping