PUBLICATION

Generation and interpretation of FGF morphogen gradients in vertebrates

Authors
Bokel, C., and Brand, M.
ID
ZDB-PUB-130610-76
Date
2013
Source
Current opinion in genetics & development   23(4): 415-22 (Review)
Registered Authors
Brand, Michael
Keywords
none
MeSH Terms
  • Animals
  • Endocytosis/genetics*
  • Fibroblast Growth Factors/genetics*
  • Gene Expression Regulation, Developmental
  • Morphogenesis/genetics*
  • Receptors, Fibroblast Growth Factor/genetics
  • Receptors, Fibroblast Growth Factor/metabolism
  • Signal Transduction/genetics
  • Vertebrates/genetics
  • Vertebrates/growth & development*
  • Zebrafish/growth & development
PubMed
23669552 Full text @ Curr. Opin. Genet. Dev.
Abstract

Signalling via fibroblast growth factors (FGFs) is involved in multiple aspects of vertebrate development. In several instances FGFs act as morphogens, that is secreted signalling molecules that encode positional information in their graded distribution throughout their target tissue. In recent years, work in the zebrafish model system has been instrumental in addressing the cell biological basis of FGF morphogen gradient formation and interpretation. These experiments have benefitted from the optical properties of the zebrafish embryo that render this vertebrate organism particularly suited for advanced microscopic and biophysical approaches.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping