PUBLICATION

Developing a sense of taste

Authors
Kapsimali, M., and Barlow, L.A.
ID
ZDB-PUB-121205-59
Date
2013
Source
Seminars in cell & developmental biology   24(3): 200-209 (Review)
Registered Authors
Kapsimali, Marika
Keywords
CVP, circumvallate papilla, RTK, tyrosine kinase receptor
MeSH Terms
  • Animals
  • Cell Differentiation
  • Epithelial-Mesenchymal Transition
  • Humans
  • Signal Transduction
  • Taste Buds/cytology
  • Taste Buds/embryology*
  • Taste Buds/growth & development
PubMed
23182899 Full text @ Sem. Cell Dev. Biol.
Abstract

Taste buds are found in a distributed array on the tongue surface, and are innervated by cranial nerves that convey taste information to the brain. For nearly a century, taste buds were thought to be induced by nerves late in embryonic development. However, this view has shifted dramatically. A host of studies now indicate that taste bud development is initiated and proceeds via processes that are nerve-independent, occur long before birth, and governed by cellular and molecular mechanisms intrinsic to the developing tongue. Here we review the state of our understanding of the molecular and cellular regulation of taste bud development, incorporating important new data obtained through the use of two powerful genetic systems, mouse and zebrafish.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping