PUBLICATION
Zebrafish as a Model to Study Drug Transporters at the Blood-Brain Barrier
- Authors
- Umans, R.A., and Taylor, M.R.
- ID
- ZDB-PUB-121016-27
- Date
- 2012
- Source
- Clinical Pharmacology and Therapeutics 92(5): 567-570 (Review)
- Registered Authors
- Taylor, Michael R.
- Keywords
- none
- MeSH Terms
-
- Animals
- Biological Transport
- Blood-Brain Barrier/metabolism*
- Brain/metabolism
- Central Nervous System/metabolism
- Drug Delivery Systems
- Endothelial Cells/metabolism
- Humans
- Membrane Transport Proteins/metabolism*
- Models, Animal*
- Pharmaceutical Preparations/metabolism*
- Zebrafish
- PubMed
- 23047649 Full text @ Clin. Pharmacol. Ther.
Citation
Umans, R.A., and Taylor, M.R. (2012) Zebrafish as a Model to Study Drug Transporters at the Blood-Brain Barrier. Clinical Pharmacology and Therapeutics. 92(5):567-570.
Abstract
The blood–brain barrier (BBB) restricts the delivery of therapeutics into the central nervous system (CNS). This limitation is due largely to localization of drug transport mechanisms to the brain endothelial cells (BECs). Although mammalian and in vitro models are currently used to study drug transport, zebrafish (Danio rerio) are advantageous for dissecting complex biological problems such as the BBB. This report focuses on zebrafish as a suitable model system for studying the BBB and drug transport.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping