PUBLICATION
Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line
- Authors
- Ou, H., Simon, J.A., Rubel, E.W., and Raible, D.W.
- ID
- ZDB-PUB-120209-4
- Date
- 2012
- Source
- Hearing Research 288(1-2): 58-66 (Review)
- Registered Authors
- Raible, David
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Death/drug effects
- Cell Survival/drug effects
- Cytoprotection
- Hair Cells, Auditory, Inner/drug effects*
- Hair Cells, Auditory, Inner/pathology
- Lateral Line System/drug effects*
- Lateral Line System/pathology
- Mass Screening/methods*
- Neuroprotective Agents/pharmacology*
- Toxicity Tests/methods*
- Zebrafish*
- PubMed
- 22310494 Full text @ Hear. Res.
Citation
Ou, H., Simon, J.A., Rubel, E.W., and Raible, D.W. (2012) Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line. Hearing Research. 288(1-2):58-66.
Abstract
The zebrafish lateral line is an efficient model system for the evaluation of chemicals that protect and damage hair cells. Located on the surface of the body, lateral line hair cells are accessible for manipulation and visualization. The zebrafish lateral line system allows rapid screens of large chemical libraries, as well as subsequent thorough evaluation of interesting compounds. In this review, we focus on the results of our previous screens and the evolving methodology of our screens for chemicals that protect hair cells, and chemicals that damage hair cells using the zebrafish lateral line.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping