PUBLICATION
Systematic Approaches to Toxicology in the Zebrafish
- Authors
- Peterson, R.T., and MacRae, C.A.
- ID
- ZDB-PUB-111111-1
- Date
- 2012
- Source
- Annual Review of Pharmacology and Toxicology 52: 433-53 (Review)
- Registered Authors
- MacRae, Calum A.
- Keywords
- none
- MeSH Terms
-
- Animals
- Carcinogenicity Tests
- Drug Delivery Systems
- Drug Design
- Drug Discovery
- Drug Evaluation, Preclinical/methods*
- Gastrointestinal Tract/drug effects
- Heart/drug effects
- Liver/drug effects
- Models, Animal
- Muscles/drug effects
- Neurons/drug effects
- Pharmaceutical Preparations
- Pharmacokinetics
- Phenotype
- Toxicity Tests*
- Zebrafish
- PubMed
- 22017682 Full text @ Annu. Rev. Pharmacol. Toxicol.
Citation
Peterson, R.T., and MacRae, C.A. (2012) Systematic Approaches to Toxicology in the Zebrafish. Annual Review of Pharmacology and Toxicology. 52:433-53.
Abstract
As the current paradigms of drug discovery evolve, it has become clear that a more comprehensive understanding of the interactions between small molecules and organismal biology will be vital. The zebrafish is emerging as a scalable vertebrate complement to existing in vitro technologies and established preclinical in vivo models. In this review, we highlight the current status of zebrafish toxicology studies, identify potential future niches for the model in the drug development pipeline, and define the hurdles that must be overcome as zebrafish technologies are refined for systematic toxicology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping