PUBLICATION
Engineering zinc finger nucleases for targeted mutagenesis of zebrafish
- Authors
- Sander, J.D., Yeh, J.R., Peterson, R.T., and Joung, J.K.
- ID
- ZDB-PUB-110921-5
- Date
- 2011
- Source
- Methods in cell biology 104: 51-58 (Chapter)
- Registered Authors
- Peterson, Randall, Yeh, Jing-Ruey (Joanna)
- Keywords
- protein engineering, reverse genetics, targeted mutagenesis, zinc finger nucleases
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cloning, Molecular
- Decision Trees
- Deoxyribonucleases, Type II Site-Specific/genetics*
- Genetic Vectors
- Mutagenesis, Site-Directed/methods
- Protein Engineering/methods*
- Reverse Genetics/methods*
- Zebrafish/genetics*
- Zinc Fingers
- PubMed
- 21924156 Full text @ Meth. Cell. Biol.
Citation
Sander, J.D., Yeh, J.R., Peterson, R.T., and Joung, J.K. (2011) Engineering zinc finger nucleases for targeted mutagenesis of zebrafish. Methods in cell biology. 104:51-58.
Abstract
Zinc finger nucleases provide an important platform for performing reverse genetics in zebrafish. Here we review various methods and resources that have been used to create customized zinc finger nucleases for use in zebrafish. We also provide a framework for choosing among the various publicly available platforms available to engineer ZFNs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping