The genetics of ocular disorders: Insights from the zebrafish
- Morris, A.C.
- Birth defects research. Part C, Embryo today : reviews 93(3): 215-228 (Review)
- Registered Authors
- Morris, Ann C.
- zebrafish, eye, ocular disease, retina, development
- MeSH Terms
- Disease Models, Animal*
- Eye Diseases/genetics*
- Vision, Ocular/genetics*
- 21932431 Full text @ Birth Defects Res. C Embryo Today
Morris, A.C. (2011) The genetics of ocular disorders: Insights from the zebrafish. Birth defects research. Part C, Embryo today : reviews. 93(3):215-228.
Proper formation of the vertebrate eye requires a precisely coordinated sequence of morphogenetic events that integrate the developmental contributions of the skin ectoderm, neuroectoderm, and head mesenchyme. Disruptions in this process result in ocular malformations or retinal degeneration and can cause significant visual impairment. The zebrafish is an excellent vertebrate model for the study of eye development and disease due to the transparency of the embryo, its ex utero development, and its amenability to forward genetic screens. This review will present an overview of the genetic methodologies utilized in the zebrafish, a description of several zebrafish models of congenital ocular diseases, and a discussion of the utility of the zebrafish for assessing the pathogenicity of candidate disease alleles.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes