ZFIN ID: ZDB-PUB-110706-7
Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in
van der Velden, Y.U., and Haramis, A.P.
Date: 2011
Source: Aging   3(4): 363-367 (Review)
Registered Authors: Haramis, Anna-Pavlina
Keywords: none
MeSH Terms:
  • Animals
  • Cell Polarity
  • Energy Metabolism
  • Humans
  • Peutz-Jeghers Syndrome/pathology
  • Peutz-Jeghers Syndrome/physiopathology
  • Protein-Serine-Threonine Kinases/genetics
  • Protein-Serine-Threonine Kinases/metabolism*
  • Signal Transduction/physiology
  • Tumor Suppressor Proteins/genetics
  • Tumor Suppressor Proteins/metabolism*
  • Zebrafish/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 21721170
The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy-metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue-specific and context-dependent effectors.