ZFIN ID: ZDB-PUB-110523-2
Development of the zebrafish enteric nervous system
Shepherd, I., and Eisen, J.
Date: 2011
Source: Methods in cell biology   101: 143-160 (Chapter)
Registered Authors: Eisen, Judith S., Shepherd, Iain T.
Keywords: enteric nervous system, intestinal tract, goblet cell, gut motility, gut musculature, mucin
MeSH Terms:
  • Animals
  • Enteric Nervous System/embryology
  • Enteric Nervous System/growth & development
  • Enteric Nervous System/physiology*
  • Gastrointestinal Motility/physiology
  • Humans
  • Zebrafish/embryology
  • Zebrafish/growth & development
  • Zebrafish/physiology*
PubMed: 21550442 Full text @ Meth. Cell. Biol.
The enteric nervous system (ENS) is composed of neurons and glia that modulate many aspects of intestinal function. The ability to use both forward and reverse genetic approaches and to visualize development in living embryos and larvae has made zebrafish an attractive model in which to study mechanisms underlying ENS development. In this chapter, we review the recent work describing the development and organization of the zebrafish ENS and how this relates to intestinal motility. We also discuss the cellular, molecular, and genetic mechanisms that have been revealed by these studies and how they are providing new insights into human ENS diseases.