PUBLICATION
Behavioral effects of MDMA ('ecstasy') on adult zebrafish
- Authors
- Stewart, A., Riehl, R., Wong, K., Green, J., Cosgrove, J., Vollmer, K., Kyzar, E., Hart, P., Allain, A., Cachat, J., Gaikwad, S., Hook, M., Rhymes, K., Newman, A., Utterback, E., Chang, K., and Kalueff, A.V.
- ID
- ZDB-PUB-110518-45
- Date
- 2011
- Source
- Behavioural pharmacology 22(3): 275-280 (Journal)
- Registered Authors
- Cachat, Jonathan, Kalueff, Allan V.
- Keywords
- none
- MeSH Terms
-
- Animals
- Behavior, Animal/drug effects*
- Brain Chemistry/drug effects
- Dose-Response Relationship, Drug
- Female
- Male
- Motor Activity/drug effects
- N-Methyl-3,4-methylenedioxyamphetamine/toxicity*
- Proto-Oncogene Proteins c-fos/analysis
- Zebrafish
- PubMed
- 21522057 Full text @ Behav. Pharmacol.
Citation
Stewart, A., Riehl, R., Wong, K., Green, J., Cosgrove, J., Vollmer, K., Kyzar, E., Hart, P., Allain, A., Cachat, J., Gaikwad, S., Hook, M., Rhymes, K., Newman, A., Utterback, E., Chang, K., and Kalueff, A.V. (2011) Behavioral effects of MDMA ('ecstasy') on adult zebrafish. Behavioural pharmacology. 22(3):275-280.
Abstract
3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a potent psychedelic drug inducing euphoria and hypersociability in humans, as well as hyperactivity and anxiety in rodents. Adult zebrafish (Danio rerio) have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/l) of acute MDMA doses on zebrafish behavior in the novel tank test. Although MDMA was inactive at lower doses (0.25-10 mg/l), higher doses reduced bottom swimming and immobility (40-120 mg/l) and impaired intrasession habituation (10-120 mg/l). MDMA also elevated brain c-fos expression, collectively confirming the usage of zebrafish models for screening of hallucinogenic compounds.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping