PUBLICATION
Large Scale Zebrafish-Based In vivo Small Molecule Screen
- Authors
- Hao, J., Williams, C.H., Webb, M.E., and Hong, C.C.
- ID
- ZDB-PUB-110124-12
- Date
- 2010
- Source
- Journal of visualized experiments : JoVE (46): (Journal)
- Registered Authors
- Hong, Charles
- Keywords
- none
- MeSH Terms
-
- Animals
- Drug Evaluation, Preclinical/methods*
- Embryo, Nonmammalian/drug effects
- Zebrafish/embryology*
- PubMed
- 21248690 Full text @ J. Vis. Exp.
Citation
Hao, J., Williams, C.H., Webb, M.E., and Hong, C.C. (2010) Large Scale Zebrafish-Based In vivo Small Molecule Screen. Journal of visualized experiments : JoVE. (46).
Abstract
Given their small embryo size, rapid development, transparency, fecundity, and numerous molecular, morphological and physiological similarities to mammals, zebrafish has emerged as a powerful in vivo platform for phenotype-based drug screens and chemical genetic analysis. Here, we demonstrate a simple, practical method for large-scale screening of small molecules using zebrafish embryos.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping