PUBLICATION

Focusing on optic tectum circuitry through the lens of genetics

Authors
Nevin, L.M., Robles, E., Baier, H., and Scott, E.K.
ID
ZDB-PUB-101011-44
Date
2010
Source
BMC Biology   8: 126 (Review)
Registered Authors
Baier, Herwig, Nevin, Linda, Robles, Estuardo, Scott, Ethan
Keywords
none
MeSH Terms
  • Animals
  • Models, Neurological*
  • Nerve Net/anatomy & histology*
  • Nerve Net/physiology
  • Neurons/physiology*
  • Superior Colliculi/anatomy & histology*
  • Superior Colliculi/physiology
  • Visual Pathways/metabolism
  • Visual Pathways/physiology*
  • Visual Perception/physiology*
  • Zebrafish
PubMed
20920150 Full text @ BMC Biol.
Abstract
The visual pathway is tasked with processing incoming signals from the retina and converting this information into adaptive behavior. Recent studies of the larval zebrafish tectum have begun to clarify how the 'micro-circuitry' of this highly organized midbrain structure filters visual input, which arrives in the superficial layers and directs motor output through efferent projections from its deep layers. The new emphasis has been on the specific function of neuronal cell types, which can now be reproducibly labeled, imaged and manipulated using genetic and optical techniques. Here, we discuss recent advances and emerging experimental approaches for studying tectal circuits as models for visual processing and sensorimotor transformation by the vertebrate brain.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping