PUBLICATION
Zebrafish epiboly: mechanics and mechanisms
- Authors
- Lepage, S.E., and Bruce, A.E.
- ID
- ZDB-PUB-100820-19
- Date
- 2010
- Source
- The International journal of developmental biology 54(8-9): 1213-1228 (Review)
- Registered Authors
- Bruce, Ashley, Lepage, Stephanie
- Keywords
- epiboly, morphogenesis, gastrulation, zebrafish, teleost, cell adhesion, radial intercalation
- MeSH Terms
-
- Animals
- Gastrula/cytology
- Gastrula/embryology*
- Gastrula/metabolism
- Gastrulation*
- Gene Expression Regulation, Developmental
- Microtubules/metabolism
- Signal Transduction/genetics
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 20712002 Full text @ Int. J. Dev. Biol.
Citation
Lepage, S.E., and Bruce, A.E. (2010) Zebrafish epiboly: mechanics and mechanisms. The International journal of developmental biology. 54(8-9):1213-1228.
Abstract
Gastrulation involves of a series of coordinated cell movements to organize the germ layers and establish the major body axes of the embryo. One gastrulation movement is epiboly, which involves the thinning and spreading of a multilayered cell sheet. Epiboly plays a prominent role in zebrafish gastrulation and studies of zebrafish epiboly have provided insights into basic cellular properties and mechanisms of morphogenesis that are widely used in animal development. Although considerable progress has been made in identifying molecules that are required for epiboly, we still understand very little about how these factors cooperate to drive the process. Here, we review work on the molecular and cellular basis of zebrafish epiboly in order to identify unifying themes and to highlight some of the current open questions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping