PUBLICATION

Global and local mechanisms of forebrain and midbrain patterning

Authors
Rhinn, M., Picker, A., and Brand, M.
ID
ZDB-PUB-100420-44
Date
2006
Source
Current opinion in neurobiology   16(1): 5-12 (Review)
Registered Authors
Brand, Michael, Rhinn, Muriel
Keywords
none
MeSH Terms
  • Animals
  • Body Patterning/physiology*
  • Bone Morphogenetic Proteins/physiology
  • Fibroblast Growth Factors/physiology
  • Gastrula/physiology
  • Mesencephalon/embryology
  • Mesencephalon/growth & development*
  • Prosencephalon/embryology
  • Prosencephalon/growth & development*
  • Signal Transduction
PubMed
16418000 Full text @ Curr. Opin. Neurobiol.
Abstract
During the past years, major advances have been made in understanding the sequential events involved in neural plate patterning. Positional information is already conferred to cells of the neural plate at the time of its induction in the ectoderm. The interplay between the BMP- and the Fgf- signaling pathways leads to the induction of neural cell fates. Thus, neural induction and neural plate patterning are overlapping processes. Later, at the end of gastrulation, positional cell identities within the neural plate are refined and maintained by the action of several neural plate organizers. By locally emitting signaling molecules, they influence the fate of the developing nervous system with high regional specificity. Recent advances have been made both in understanding the mechanisms that dictate the relative position of these organizers and in how signaling molecules spread from them with high spatial and temporal resolution.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes