PUBLICATION
An automatic quantification and registration strategy to create a gene expression atlas of zebrafish embryogenesis
- Authors
- Castro, C., Luengo-Oroz, M.A., Desnoulez, S., Duloquin, L., Fernandez-de-Manuel, L., Montagna, S., Ledesma-Carbayo, M.J., Bourgine, P., Peyrieras, N., and Santos, A.
- ID
- ZDB-PUB-091215-45
- Date
- 2009
- Source
- Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 1: 1469-1472 (Journal)
- Registered Authors
- Duloquin, Louise
- Keywords
- none
- MeSH Terms
-
- Animals
- Automation*
- Gene Expression Regulation, Developmental*
- Zebrafish/embryology*
- PubMed
- 19963501 Full text @ Conf. Proc. IEEE Eng. Med. Biol. Soc.
Citation
Castro, C., Luengo-Oroz, M.A., Desnoulez, S., Duloquin, L., Fernandez-de-Manuel, L., Montagna, S., Ledesma-Carbayo, M.J., Bourgine, P., Peyrieras, N., and Santos, A. (2009) An automatic quantification and registration strategy to create a gene expression atlas of zebrafish embryogenesis. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 1:1469-1472.
Abstract
In order to properly understand and model the gene regulatory networks in animals development, it is crucial to obtain detailed measurements, both in time and space, about their gene expression domains. In this paper, we propose a complete computational framework to fulfill this task and create a 3D Atlas of the early zebrafish embryogenesis annotated with both the cellular localizations and the level of expression of different genes at different developmental stages. The strategy to construct such an Atlas is described here with the expression pattern of 5 different genes at 6 hours of development post fertilization.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping