PUBLICATION
The genetics of cardiovascular disease: new insights from emerging approaches
- Authors
- Chico, T.J., Milo, M., and Crossman, D.C.
- ID
- ZDB-PUB-091120-64
- Date
- 2010
- Source
- The Journal of pathology 220(2): 186-197 (Review)
- Registered Authors
- Chico, Tim J.
- Keywords
- microRNA, genome-wide association studies, deep sequencing, high-throughput sequencing, zebrafish, genetics
- MeSH Terms
-
- Animals
- Cardiovascular Diseases/genetics*
- Disease Models, Animal
- Genetic Predisposition to Disease
- Genome-Wide Association Study/methods*
- Humans
- MicroRNAs/genetics
- Polymorphism, Single Nucleotide
- Zebrafish
- PubMed
- 19921712 Full text @ J. Pathol.
Citation
Chico, T.J., Milo, M., and Crossman, D.C. (2010) The genetics of cardiovascular disease: new insights from emerging approaches. The Journal of pathology. 220(2):186-197.
Abstract
The prospect that sequencing the human genome would see rapid translation of a greater understanding of cardiovascular genetics into novel diagnostics and therapeutics has so far met with only limited success. However, diverse technological advances and exploitation of novel animal models of cardiovascular development and disease are providing ever more insight into cardiovascular diseases and development, and bring closer the prospect of 'post-genomic' diagnostics and therapies. Here we review some of these emerging approaches (genome wide association studies, deep sequencing, microRNA regulation, and zebrafish as a model of cardiovascular disease and development) and discuss their potential for finally fulfilling the promise of application to clinical cardiovascular medicine. Copyright (c) 2009 Pathological Society of Great Britain and Ireland.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping