PUBLICATION
Specification, maintenance and fate determination of neural progenitor pools in the zebrafish central nervous system
- Authors
- Stigloher, C.
- ID
- ZDB-PUB-090521-153
- Date
- 2008
- Source
- Ph.D. Thesis : (Thesis)
- Registered Authors
- Stigloher, Christian
- Keywords
- central nervous system, zebrafish, progenitor status, midbrain-hindbrain boundary, eye field
- MeSH Terms
- none
- PubMed
- none
Citation
Stigloher, C. (2008) Specification, maintenance and fate determination of neural progenitor pools in the zebrafish central nervous system. Ph.D. Thesis. .
Abstract
This thesis contributes to the deeper understanding of the processes of specification and maintenance of neural progenitor pools and to the mechanisms of fate determination in the central nervous system of the zebrafish. The focus of this work lies on the progenitor pools of the eye field and the midbrain-hindbrain boundary. E(Spl) genes and microRNA 9 could be identified as factors that are crucially implicated in the control of the progenitor status. Furthermore, molecular and cellular differences of progenitors within the midbrain-hindbrain domain and the role of a timer mechanism in cell fate determination were analyzed. With the help of comparative studies parallels and differences between progenitor pools in the embryonic and adult brain could be identified.
Errata / Notes
Dissertation, Munchen, Techn. Univ.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping