ZFIN ID: ZDB-PUB-081218-28
Building an asymmetric brain: Development of the zebrafish epithalamus
Snelson, C.D., and Gamse, J.T.
Date: 2009
Source: Seminars in Cell & Developmental Biology 20(4): 491-497 (Review)
Registered Authors: Gamse, Josh, Snelson, Corey
Keywords: Brain Asymmetry, Epithalamus, Parapineal, Review, Zebrafish
MeSH Terms: Animals; Brain/embryology*; Embryonic Development; Epithalamus/embryology*; Functional Laterality* (all 6) expand
PubMed: 19084075 Full text @ Semin. Cell Dev. Biol.
ABSTRACT
The human brain exhibits notable asymmetries. Little is known about these symmetry deviations, however scientists are beginning to understand them by employing the lateralized zebrafish epithalamus as a model. The zebrafish epithalamus consists of the pineal and parapineal organs and paired habenular nuclei located bilaterally to the pineal complex. While zebrafish pineal and parapineal organs arise from a common population of cells, parapineal cells undergo a separate program that allows them to migrate left of the pineal anlage. Studying the processes that lead to brain laterality in zebrafish will allow a better understanding of how human brain laterality is established.
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