ZFIN ID: ZDB-PUB-081218-28
Building an asymmetric brain: Development of the zebrafish epithalamus
Snelson, C.D., and Gamse, J.T.
Date: 2009
Source: Seminars in Cell & Developmental Biology 20(4): 491-497 (Review)
Registered Authors: Gamse, Josh, Snelson, Corey
Keywords: Brain Asymmetry, Epithalamus, Parapineal, Review, Zebrafish
MeSH Terms:
  • Animals
  • Brain/embryology*
  • Embryonic Development
  • Epithalamus/embryology*
  • Functional Laterality*
  • Zebrafish
PubMed: 19084075 Full text @ Semin. Cell Dev. Biol.
The human brain exhibits notable asymmetries. Little is known about these symmetry deviations, however scientists are beginning to understand them by employing the lateralized zebrafish epithalamus as a model. The zebrafish epithalamus consists of the pineal and parapineal organs and paired habenular nuclei located bilaterally to the pineal complex. While zebrafish pineal and parapineal organs arise from a common population of cells, parapineal cells undergo a separate program that allows them to migrate left of the pineal anlage. Studying the processes that lead to brain laterality in zebrafish will allow a better understanding of how human brain laterality is established.