PUBLICATION

The neurogenetic frontier--lessons from misbehaving zebrafish

Authors
Burgess, H.A., and Granato, M.
ID
ZDB-PUB-081008-16
Date
2008
Source
Briefings in functional genomics & proteomics   7(6): 474-482 (Review)
Registered Authors
Burgess, Harold, Granato, Michael
Keywords
zebrafish, behavior, mutagenesis
MeSH Terms
  • Animals
  • Genetic Testing/methods
  • Genetics, Behavioral*
  • Mutation
  • Zebrafish/genetics*
  • Zebrafish/physiology
PubMed
18836206 Full text @ Brief. Funct. Genomic. Proteomic.
Abstract
One of the central questions in neuroscience is how refined patterns of connectivity in the brain generate and monitor behavior. Genetic mutations can influence neural circuits by disrupting differentiation or maintenance of component neuronal cells or by altering functional patterns of nervous system connectivity. Mutagenesis screens therefore have the potential to reveal not only the molecular underpinnings of brain development and function, but to illuminate the cellular basis of behavior. Practical considerations make the zebrafish an organism of choice for undertaking forward genetic analysis of behavior. The powerful array of experimental tools at the disposal of the zebrafish researcher makes it possible to link molecular function to neuronal properties that underlie behavior. This review focuses on specific challenges to isolating and analyzing behavioral mutants in zebrafish.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping