PUBLICATION
Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes
- Authors
- Novak, A.E., Taylor, A.D., Pineda, R.H., Lasda, E.L., Wright, M.A., and Ribera, A.B.
- ID
- ZDB-PUB-060419-6
- Date
- 2006
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 235(7): 1962-1973 (Journal)
- Registered Authors
- Novak, Alicia, Pineda, Ricardo, Ribera, Angie
- Keywords
- zebrafish, SCNA gene, electrical signaling, Nav1 protein, skeletal muscle, cardiac muscle, nervous system, spinal cord
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Embryo, Nonmammalian/metabolism
- Gene Expression Regulation, Developmental
- Ion Channel Gating
- Larva/metabolism
- Molecular Sequence Data
- Myocardium/metabolism
- Protein Subunits/genetics
- Protein Subunits/metabolism
- Sodium Channels/genetics
- Sodium Channels/metabolism*
- Zebrafish/embryology*
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 16615064 Full text @ Dev. Dyn.
Citation
Novak, A.E., Taylor, A.D., Pineda, R.H., Lasda, E.L., Wright, M.A., and Ribera, A.B. (2006) Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(7):1962-1973.
Abstract
Whereas it is known that voltage-gated calcium channels play important roles during development, potential embryonic roles of voltage-gated sodium channels have received much less attention. Voltage-gated sodium channels consist of pore-forming alpha-subunits (Na(v)1) and auxiliary beta-subunits. Here, we report the embryonic and larval expression patterns for all eight members of the gene family (scna) coding for zebrafish Na(v)1 proteins. We find that each scna gene displays a distinct expression pattern that is temporally and spatially dynamic during embryonic and larval stages. Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping