PUBLICATION
Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): Differential involvement in the visceral skeleton and braincase
- Authors
- Verreijdt, L., Debiais-Thibaud, M., Borday-Birraux, V., Van der Heyden, C., Sire, J.Y., and Huysseune, A.
- ID
- ZDB-PUB-060323-13
- Date
- 2006
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 235(5): 1371-1389 (Journal)
- Registered Authors
- Borday, Veronique, Debiais-Thibaud, Mélanie, Huysseune, Ann, Sire, Jean-Yves, van der Heyden, Christine, Verreijdt, Liesbeth
- Keywords
- zebrafish, Danio rerio, dermal bones, cartilage bones, dlx genes, braincase, visceral skeleton
- MeSH Terms
-
- Animals
- Homeodomain Proteins/biosynthesis
- Homeodomain Proteins/genetics*
- Multigene Family
- Osteogenesis/genetics
- Skull/embryology*
- Skull/metabolism
- Skull/physiology
- Transcription Factors/biosynthesis
- Transcription Factors/genetics*
- Zebrafish/embryology*
- Zebrafish/metabolism
- Zebrafish/physiology
- Zebrafish Proteins/biosynthesis
- Zebrafish Proteins/genetics
- PubMed
- 16534783 Full text @ Dev. Dyn.
Citation
Verreijdt, L., Debiais-Thibaud, M., Borday-Birraux, V., Van der Heyden, C., Sire, J.Y., and Huysseune, A. (2006) Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): Differential involvement in the visceral skeleton and braincase. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(5):1371-1389.
Abstract
We have used dlx genes to test the hypothesis of a separate developmental program for dermal and cartilage bones within the neuro- and splanchnocranium by comparing expression patterns of all eight dlx genes during cranial bone formation in zebrafish from 1 day postfertilization (dPF) to 15 dPF. dlx genes are expressed in the visceral skeleton but not during the formation of dermal or cartilage bones of the braincase. The spatiotemporal expression pattern of all the members of the dlx gene family, support the view that dlx genes impart cellular identity to the different arches, required to make arch-specific dermal bones. Expression patterns seemingly associated with cartilage (perichondral) bones of the arches, in contrast, are probably related to ongoing differentiation of the underlying cartilage rather than with differentiation of perichondral bones themselves. Whether dlx genes originally functioned in the visceral skeleton only, and whether their involvement in the formation of neurocranial bones (as in mammals) is secondary, awaits clarification.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping