PUBLICATION

Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): Differential involvement in the visceral skeleton and braincase

Authors
Verreijdt, L., Debiais-Thibaud, M., Borday-Birraux, V., Van der Heyden, C., Sire, J.Y., and Huysseune, A.
ID
ZDB-PUB-060323-13
Date
2006
Source
Developmental dynamics : an official publication of the American Association of Anatomists   235(5): 1371-1389 (Journal)
Registered Authors
Borday, Veronique, Debiais-Thibaud, Mélanie, Huysseune, Ann, Sire, Jean-Yves, van der Heyden, Christine, Verreijdt, Liesbeth
Keywords
zebrafish, Danio rerio, dermal bones, cartilage bones, dlx genes, braincase, visceral skeleton
MeSH Terms
  • Animals
  • Homeodomain Proteins/biosynthesis
  • Homeodomain Proteins/genetics*
  • Multigene Family
  • Osteogenesis/genetics
  • Skull/embryology*
  • Skull/metabolism
  • Skull/physiology
  • Transcription Factors/biosynthesis
  • Transcription Factors/genetics*
  • Zebrafish/embryology*
  • Zebrafish/metabolism
  • Zebrafish/physiology
  • Zebrafish Proteins/biosynthesis
  • Zebrafish Proteins/genetics
PubMed
16534783 Full text @ Dev. Dyn.
Abstract
We have used dlx genes to test the hypothesis of a separate developmental program for dermal and cartilage bones within the neuro- and splanchnocranium by comparing expression patterns of all eight dlx genes during cranial bone formation in zebrafish from 1 day postfertilization (dPF) to 15 dPF. dlx genes are expressed in the visceral skeleton but not during the formation of dermal or cartilage bones of the braincase. The spatiotemporal expression pattern of all the members of the dlx gene family, support the view that dlx genes impart cellular identity to the different arches, required to make arch-specific dermal bones. Expression patterns seemingly associated with cartilage (perichondral) bones of the arches, in contrast, are probably related to ongoing differentiation of the underlying cartilage rather than with differentiation of perichondral bones themselves. Whether dlx genes originally functioned in the visceral skeleton only, and whether their involvement in the formation of neurocranial bones (as in mammals) is secondary, awaits clarification.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes