PUBLICATION

Chemical Genetics: Drug Screens in Zebrafish

Authors
den Hertog, J.
ID
ZDB-PUB-051128-11
Date
2005
Source
Bioscience Reports   25(5-6): 289-297 (Journal)
Registered Authors
den Hertog, Jeroen
Keywords
Chemical genetics, zebrafish, development, compounds, inhibitors, drug target, disease
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Drug Evaluation, Preclinical/methods*
  • Models, Biological
  • Models, Genetic
  • Mutagenesis
  • Pharmacogenetics/methods*
  • Toxicity Tests
  • Zebrafish/embryology
  • Zebrafish/metabolism*
  • Zebrafish/physiology*
PubMed
16307377 Full text @ Biosci. Rep.
Abstract
High throughput chemical genetic screens for compounds with specific biological activity in a whole organism are feasible using zebrafish embryos. At least two medium to large scale drug screens have been carried out to date, leading to the identification of compounds that disturb zebrafish development. Chemical genetics using zebrafish embryos may become an important step in the discovery of drugs and their targets.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping