PUBLICATION
Chemical Genetics: Drug Screens in Zebrafish
- Authors
- den Hertog, J.
- ID
- ZDB-PUB-051128-11
- Date
- 2005
- Source
- Bioscience Reports 25(5-6): 289-297 (Journal)
- Registered Authors
- den Hertog, Jeroen
- Keywords
- Chemical genetics, zebrafish, development, compounds, inhibitors, drug target, disease
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Drug Evaluation, Preclinical/methods*
- Models, Biological
- Models, Genetic
- Mutagenesis
- Pharmacogenetics/methods*
- Toxicity Tests
- Zebrafish/embryology
- Zebrafish/metabolism*
- Zebrafish/physiology*
- PubMed
- 16307377 Full text @ Biosci. Rep.
Citation
den Hertog, J. (2005) Chemical Genetics: Drug Screens in Zebrafish. Bioscience Reports. 25(5-6):289-297.
Abstract
High throughput chemical genetic screens for compounds with specific biological activity in a whole organism are feasible using zebrafish embryos. At least two medium to large scale drug screens have been carried out to date, leading to the identification of compounds that disturb zebrafish development. Chemical genetics using zebrafish embryos may become an important step in the discovery of drugs and their targets.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping