PUBLICATION
Characterization of TCDD-induced craniofacial malformations and retardation of zebrafish growth
- Authors
- Hill, A., Howard, V., and Cossins, A.
- ID
- ZDB-PUB-050621-2
- Date
- 2004
- Source
- Journal of Fish Biology 64(4): 911 (Journal)
- Registered Authors
- Hill, Adrian
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none
Citation
Hill, A., Howard, V., and Cossins, A. (2004) Characterization of TCDD-induced craniofacial malformations and retardation of zebrafish growth. Journal of Fish Biology. 64(4):911.
Abstract
The documented 2,3,7,8tetrachlorodibenzopdioxin (TCDD) induced effects on zebrafish Danio rerio including craniofacial malformations and a general retardation of growth, were further characterized in the present study. A significant decrease in total body length and the length of each bone in the upper and lower jaw was identified in exposed larvae from an exposure concentration of 30 ng l1 TCDD. This study is the first quantitative evidence for the effects of TCDD on the upper jaw and also demonstrates that TCDD induced craniofacial malformations and retardation of growth are very sensitive endpoints of dioxin toxicity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping